Interaction between bone morphogenetic protein receptor type 2 and estrogenic compounds in pulmonary arterial hypertension

Abstract. The majority of heritable pulmonary arterial hypertension (HPAH) cases are associated with mutations in bone morphogenetic protein receptor type 2 (BMPR2). BMPR2 mutation carries about a 20% lifetime risk of PAH development, but penetrance is approximately three times higher in females. Pr...

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Main Authors: Fessel, Joshua P., Chen, Xinping, Frump, Andrea, Gladson, Santhi, Blackwell, Tom, Kang, Christie, Johnson, Jennifer, Loyd, James E., Hemnes, Anna, Austin, Eric, West, James
Format: Artigo
Jezik:Inglês
Izdano: University of Chicago Press 2013
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4070799/
https://ncbi.nlm.nih.gov/pubmed/24618541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/674312
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