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Selective endothelin-A receptor blockade attenuates endotoxin-induced pulmonary hypertension and pulmonary vascular dysfunction

Abstract. Endothelin-1 is a potent mediator of sepsis-induced pulmonary hypertension (PH). The pulmonary vascular effects of selective blockade of endothelin receptor subtype A (ET(A)R) during endotoxemia remain unknown. We hypothesized that selective ET(A)R antagonism attenuates endotoxin-induced P...

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Detalhes bibliográficos
Main Authors: Toney, Brent M., Fisher, Amanda J., Albrecht, Marjorie, Lockett, Angelia D., Presson, Robert G., Petrache, Irina, Lahm, Tim
Formato: Artigo
Idioma:Inglês
Publicado em: University of Chicago Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4070772/
https://ncbi.nlm.nih.gov/pubmed/25006449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/675993
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