In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo(Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH(2)) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and acts as a bronchodilator

The pharmacological and airways relaxant profiles of PL-3994 (Hept-cyclo(Cys-His-Phe-d-Ala-Gly-Arg-dNle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH(2)), a novel natriuretic peptide receptor-A (NPR-A) agonist, were evaluated. PL-3994, a full agonist, has high affinity for recombinant human (h), dog, or...

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Detalhes bibliográficos
Main Authors: Edelson, Jeffrey D., Makhlina, Marie, Silvester, Kevin R., Vengurlekar, Shailesh S., Chen, Xiaomei, Zhang, Jie, Koziol-White, Cynthia J., Cooper, Philip R., Hallam, Trevor J., Hay, Douglas W.P., Panettieri, Reynold A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4070431/
https://ncbi.nlm.nih.gov/pubmed/23154072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pupt.2012.11.001
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