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Cross-Linking of Thioredoxin Reductase by the Sulfur Mustard Analogue Mechlorethamine (Methyl bis(2-chloroethyl) amine) in Human Lung Epithelial Cells and Rat Lung: Selective Inhibition of Disulfide Reduction but Not Redox Cycling

Oxidative stress plays a key role in mechlorethamine (methyl bis(2-chloroethyl) amine, HN2) toxicity. The thioredoxin system, consisting of thioredoxin reductase (TrxR), thioredoxin, and NADPH, is important in redox regulation and protection against oxidative stress. HN2 contains two electrophilic s...

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Библиографические подробности
Главные авторы: Jan, Yi-Hua, Heck, Diane E., Malaviya, Rama, Casillas, Robert P., Laskin, Debra L., Laskin, Jeffrey D.
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4070429/
https://ncbi.nlm.nih.gov/pubmed/24274902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx400329a
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