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Many Approved Drugs Have Bioactive Analogs With Different Target Annotations

Close structural relationships between approved drugs and bioactive compounds were systematically assessed using matched molecular pairs. For structural analogs of drugs, target information was assembled from ChEMBL and compared to drug targets reported in DrugBank. For many drugs, multiple analogs...

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Detalhes bibliográficos
Main Authors: Hu, Ye, Lounkine, Eugen, Bajorath, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4070249/
https://ncbi.nlm.nih.gov/pubmed/24871342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9621-8
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