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Why Human Disease-Associated Residues Appear as the Wild-Type in Other Species: Genome-Scale Structural Evidence for the Compensation Hypothesis

Many human-disease associated amino acid residues (DARs) appear as the wild-type in other species. This phenomenon is commonly explained by the presence of compensatory residues in these other species that alleviate the deleterious effects of the DARs. The general validity of this hypothesis, howeve...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Xu, Jinrui, Zhang, Jianzhi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4069617/
https://ncbi.nlm.nih.gov/pubmed/24723421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msu130
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