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Why Human Disease-Associated Residues Appear as the Wild-Type in Other Species: Genome-Scale Structural Evidence for the Compensation Hypothesis

Many human-disease associated amino acid residues (DARs) appear as the wild-type in other species. This phenomenon is commonly explained by the presence of compensatory residues in these other species that alleviate the deleterious effects of the DARs. The general validity of this hypothesis, howeve...

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Detalhes bibliográficos
Main Authors: Xu, Jinrui, Zhang, Jianzhi
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4069617/
https://ncbi.nlm.nih.gov/pubmed/24723421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msu130
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