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Why are viral genomes so fragile? The bottleneck hypothesis
If they undergo new mutations at each replication cycle, why are RNA viral genomes so fragile, with most mutations being either strongly deleterious or lethal? Here we provide theoretical and numerical evidence for the hypothesis that genetic fragility is partly an evolutionary response to the multi...
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| Publicado no: | PLoS Comput Biol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8291636/ https://ncbi.nlm.nih.gov/pubmed/34237053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1009128 |
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