Caffeic Acid Derivatives Inhibit the Growth of Colon Cancer: Involvement of the PI3-K/Akt and AMPK Signaling Pathways

BACKGROUND: The aberrant regulation of phosphatidylinositide 3-kinases (PI3-K)/Akt, AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (m-TOR) signaling pathways in cancer has prompted significant interest in the suppression of these pathways to treat cancer. Caffeic acid (CA) has...

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Главные авторы: Chiang, En-Pei Isabel, Tsai, Shu-Yao, Kuo, Yueh-Hsiung, Pai, Man-Hui, Chiu, Hsi-Lin, Rodriguez, Raymond L., Tang, Feng-Yao
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2014
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4069067/
https://ncbi.nlm.nih.gov/pubmed/24960186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099631
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