Pyrrolidinyl caffeamide against ischemia/reperfusion injury in cardiomyocytes through AMPK/AKT pathways

BACKGROUND: Coronary heart disease is a leading cause of death in the world and therapy to reduce injury is still needed. The uncoupling of glycolysis and glucose oxidation induces lactate accumulation during myocardial ischemia/reperfusion (I/R) injury. Cell death occurs and finally leads to myocar...

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Udgivet i:J Biomed Sci
Main Authors: Lee, Shih-Yi, Ku, Hui-Chun, Kuo, Yueh-Hsiung, Chiu, His-Lin, Su, Ming-Jai
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367820/
https://ncbi.nlm.nih.gov/pubmed/25879197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-015-0125-3
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