Inhibition of Aminoglycoside 6′-N-Acetyltransferase Type Ib by Zinc: Reversal of Amikacin Resistance in Acinetobacter baumannii and Escherichia coli by a Zinc Ionophore

In vitro activity of the aminoglycoside 6′-N-acetyltransferase type Ib [AAC(6′)-Ib] was inhibited by ZnCl(2) with a 50% inhibitory concentration (IC(50)) of 15 μM. Growth of Acinetobacter baumannii or Escherichia coli harboring aac(6′)-Ib in cultures containing 8 μg/ml amikacin was significantly inh...

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Autores principales: Lin, David L., Tran, Tung, Alam, Jamal Y., Herron, Steven R., Ramirez, Maria Soledad, Tolmasky, Marcelo E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2014
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068593/
https://ncbi.nlm.nih.gov/pubmed/24820083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00129-14
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