Pharmacokinetic and Pharmacodynamic Evaluation of AZD5847 in a Mouse Model of Tuberculosis

AZD5847, a novel oxazolidinone with an MIC of 1 μg/ml, exhibits exposure-dependent killing kinetics against extracellular and intracellular Mycobacterium tuberculosis. Oral administration of AZD5847 to mice infected with M. tuberculosis H37Rv in a chronic-infection model resulted in a 1.0-log(10) re...

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Main Authors: Balasubramanian, V., Solapure, Suresh, Shandil, Radha, Gaonkar, Sheshagiri, Mahesh, K. N., Reddy, Jitender, Deshpande, Abhijeet, Bharath, Sowmya, Kumar, Naveen, Wright, Lindsay, Melnick, David, Butler, Scott L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068583/
https://ncbi.nlm.nih.gov/pubmed/24820085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00137-14
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