Moxifloxacin, Ofloxacin, Sparfloxacin, and Ciprofloxacin against Mycobacterium tuberculosis: Evaluation of In Vitro and Pharmacodynamic Indices That Best Predict In Vivo Efficacy

Members of the fluoroquinolone class are being actively evaluated for inclusion in tuberculosis chemotherapy regimens, and we sought to determine the best in vitro and pharmacodynamic predictors of in vivo efficacy in mice. MICs for Mycobacterium tuberculosis H37Rv were 0.1 mg/liter (sparfloxacin [S...

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Autori principali: Shandil, Radha K., Jayaram, Ramesh, Kaur, Parvinder, Gaonkar, Sheshagiri, Suresh, B. L., Mahesh, B. N., Jayashree, R., Nandi, Vrinda, Bharath, Sowmya, Balasubramanian, V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2007
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797767/
https://ncbi.nlm.nih.gov/pubmed/17145798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00414-06
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