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A Highly Active and Negatively Charged Streptococcus pyogenes Lysin with a Rare d-Alanyl-l-Alanine Endopeptidase Activity Protects Mice against Streptococcal Bacteremia

Bacteriophage endolysins have shown great efficacy in killing Gram-positive bacteria. PlyC, a group C streptococcal phage lysin, represents the most efficient lysin characterized to date, with a remarkably high specificity against different streptococcal species, including the important pathogen Str...

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Detalhes bibliográficos
Main Authors: Lood, Rolf, Raz, Assaf, Molina, Henrik, Euler, Chad W., Fischetti, Vincent A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068442/
https://ncbi.nlm.nih.gov/pubmed/24637688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00115-14
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