Assessment of Mycobacterium tuberculosis Pantothenate Kinase Vulnerability through Target Knockdown and Mechanistically Diverse Inhibitors

Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenate, the first committed and rate-limiting step toward coenzyme A (CoA) biosynthesis. In our earlier reports, we had established that the type I isoform encoded by the coaA gene is an essential pantothenate kinase in Mycobacterium...

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Detalhes bibliográficos
Main Authors: Reddy, B. K. Kishore, Landge, Sudhir, Ravishankar, Sudha, Patil, Vikas, Shinde, Vikas, Tantry, Subramanyam, Kale, Manoj, Raichurkar, Anandkumar, Menasinakai, Sreenivasaiah, Mudugal, Naina Vinay, Ambady, Anisha, Ghosh, Anirban, Tunduguru, Ragadeepthi, Kaur, Parvinder, Singh, Ragini, Kumar, Naveen, Bharath, Sowmya, Sundaram, Aishwarya, Bhat, Jyothi, Sambandamurthy, Vasan K., Björkelid, Christofer, Jones, T. Alwyn, Das, Kaveri, Bandodkar, Balachandra, Malolanarasimhan, Krishnan, Mukherjee, Kakoli, Ramachandran, Vasanthi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068421/
https://ncbi.nlm.nih.gov/pubmed/24687493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00140-14
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