Assessment of Mycobacterium tuberculosis Pantothenate Kinase Vulnerability through Target Knockdown and Mechanistically Diverse Inhibitors

Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenate, the first committed and rate-limiting step toward coenzyme A (CoA) biosynthesis. In our earlier reports, we had established that the type I isoform encoded by the coaA gene is an essential pantothenate kinase in Mycobacterium...

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Main Authors: Reddy, B. K. Kishore, Landge, Sudhir, Ravishankar, Sudha, Patil, Vikas, Shinde, Vikas, Tantry, Subramanyam, Kale, Manoj, Raichurkar, Anandkumar, Menasinakai, Sreenivasaiah, Mudugal, Naina Vinay, Ambady, Anisha, Ghosh, Anirban, Tunduguru, Ragadeepthi, Kaur, Parvinder, Singh, Ragini, Kumar, Naveen, Bharath, Sowmya, Sundaram, Aishwarya, Bhat, Jyothi, Sambandamurthy, Vasan K., Björkelid, Christofer, Jones, T. Alwyn, Das, Kaveri, Bandodkar, Balachandra, Malolanarasimhan, Krishnan, Mukherjee, Kakoli, Ramachandran, Vasanthi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
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Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068421/
https://ncbi.nlm.nih.gov/pubmed/24687493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00140-14
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