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Gleevec/imatinib, an ABL2 kinase inhibitor, protects tumor and endothelial cells from semaphorin-induced cytoskeleton collapse and loss of cell motility
Class 3 semaphorins are axonal guidance mediators and regulators of angiogenesis and tumor progression Semaphorin 3A and 3F (SEMA3A&F) act by depolymerizing F-actin, resulting in cytoskeleton collapse A key signaling step is that SEMA3A&F activates ABL2 tyrosine kinase, which activates p190R...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4068341/ https://ncbi.nlm.nih.gov/pubmed/24759231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2014.04.063 |
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