Gyramides Prevent Bacterial Growth by Inhibiting DNA Gyrase and Altering Chromosome Topology

[Image: see text] Antibiotics targeting DNA gyrase have been a clinical success story for the past half-century, and the emergence of bacterial resistance has fueled the search for new gyrase inhibitors. In this paper we demonstrate that a new class of gyrase inhibitors, the gyramides, are bacterios...

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Bibliographic Details
Main Authors: Rajendram, Manohary, Hurley, Katherine A., Foss, Marie H., Thornton, Kelsey M., Moore, Jared T., Shaw, Jared T., Weibel, Douglas B.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068256/
https://ncbi.nlm.nih.gov/pubmed/24712739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500154m
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