Mitochondrial DNA Variant in COX1 Subunit Significantly Alters Energy Metabolism of Geographically Divergent Wild Isolates in Caenorhabditis elegans

Mitochondrial DNA (mtDNA) sequence variation can influence the penetrance of complex diseases and climatic adaptation. While studies in geographically defined human populations suggest that mtDNA mutations become fixed when they have conferred metabolic capabilities optimally suited for a specific e...

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Detalhes bibliográficos
Main Authors: Dingley, Stephen D., Polyak, Erzsebet, Ostrovsky, Julian, Srinivasan, Satish, Lee, Icksoo, Rosenfeld, Amy B., Tsukikawa, Mai, Xiao, Rui, Selak, Mary A., Coon, Joshua J., Hebert, Alexander S., Grimsrud, Paul A., Kwon, Young Joon, Pagliarini, David J., Gai, Xiaowu, Schurr, Theodore G., Hüttemann, Maik, Nakamaru-Ogiso, Eiko, Falk, Marni J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067970/
https://ncbi.nlm.nih.gov/pubmed/24534730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2014.02.009
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