Direct Observations of Amyloid β Self-Assembly in Live Cells Provide Insights into Differences in the Kinetics of Aβ(1–40) and Aβ(1–42) Aggregation

Insight into how amyloid β (Aβ) aggregation occurs in vivo is vital for understanding the molecular pathways that underlie Alzheimer’s disease and requires new techniques that provide detailed kinetic and mechanistic information. Using noninvasive fluorescence lifetime recordings, we imaged the form...

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Detalhes bibliográficos
Main Authors: Esbjörner, Elin K., Chan, Fiona, Rees, Eric, Erdelyi, Miklos, Luheshi, Leila M., Bertoncini, Carlos W., Kaminski, Clemens F., Dobson, Christopher M., Kaminski Schierle, Gabriele S.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067742/
https://ncbi.nlm.nih.gov/pubmed/24856820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.03.014
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