Isoaspartyl Formation in Creatine Kinase B Is Associated with Loss of Enzymatic Activity; Implications for the Linkage of Isoaspartate Accumulation and Neurological Dysfunction in the PIMT Knockout Mouse

Isoaspartate (isoAsp) formation is a common type of spontaneous protein damage that is normally kept in check by the repair enzyme protein-L-isoaspartyl methyltransferase (PIMT). PIMT-KO (knockout) mice exhibit a pronounced neuropathology highlighted by death from an epileptic seizure at 30 to 60 da...

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Détails bibliographiques
Auteurs principaux: Dimitrijevic, Aleksandra, Qin, Zhenxia, Aswad, Dana W.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067349/
https://ncbi.nlm.nih.gov/pubmed/24955845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100622
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