Isoaspartate Accumulation in Mouse Brain Is Associated with Altered Patterns of Protein Phosphorylation and Acetylation, Some of Which Are Highly Sex-Dependent

Isoaspartate (isoAsp) formation is a major source of protein damage that is kept in check by the repair function of protein L-isoaspartyl methyltransferase (PIMT). Mice deficient in PIMT accumulate isoAsp-containing proteins, resulting in cognitive deficits, abnormal neuronal physiology and cytoarch...

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Bibliographic Details
Main Authors: Qin, Zhenxia, Kaufman, Rachel S., Khoury, Rana N., Khoury, Mitri K., Aswad, Dana W.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3818261/
https://ncbi.nlm.nih.gov/pubmed/24224061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080758
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