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Accelerated protein damage in brains of PIMT +/− mice; a possible model for the variability of cognitive decline in human aging
Isoaspartate formation is a common type of protein damage normally kept in check by the repair enzyme protein-L-isoaspartyl methyltransferase (PIMT). Mice with a knockout of the gene (Pcmt1) for this enzyme (KO −/−) exhibit a pronounced neuropathology with fatal epileptic seizures at 30-60 days. HZ...
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| Published in: | Neurobiol Aging |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4315693/ https://ncbi.nlm.nih.gov/pubmed/25465735 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2014.10.036 |
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