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Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A
Botulinum neurotoxins (BoNTs) inhibit neurotransmitter release by hydrolysing SNARE proteins. The most important serotype BoNT/A employs the synaptic vesicle glycoprotein 2 (SV2) isoforms A-C as neuronal receptors. Here, we identified their binding site by blocking SV2 interaction using monoclonal a...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4067265/ https://ncbi.nlm.nih.gov/pubmed/24583011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2014.02.034 |
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