Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A

Botulinum neurotoxins (BoNTs) inhibit neurotransmitter release by hydrolysing SNARE proteins. The most important serotype BoNT/A employs the synaptic vesicle glycoprotein 2 (SV2) isoforms A-C as neuronal receptors. Here, we identified their binding site by blocking SV2 interaction using monoclonal a...

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Autores principales: Strotmeier, Jasmin, Mahrhold, Stefan, Krez, Nadja, Janzen, Constantin, Lou, Jianlong, Marks, James D., Binz, Thomas, Rummel, Andreas
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067265/
https://ncbi.nlm.nih.gov/pubmed/24583011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2014.02.034
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