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Cdh1, a Substrate-recruiting Component of Anaphase-promoting Complex/Cyclosome (APC/C) Ubiquitin E3 Ligase, Specifically Interacts with Phosphatase and Tensin Homolog (PTEN) and Promotes Its Removal from Chromatin

A pool of PTEN localizes to the nucleus. However, the exact mechanism by which nuclear PTEN is regulated remains unclear. We have recently reported that Plk1 specifically phosphorylates PTEN on Ser-380 during mitosis. Here we report that PTEN also localized to chromatin and that chromatin PTEN was r...

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Detalles Bibliográficos
Autores principales: Choi, Byeong Hyeok, Pagano, Michele, Huang, Chaunshu, Dai, Wei
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067225/
https://ncbi.nlm.nih.gov/pubmed/24811168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.559005
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