Corin Mutations K317E and S472G from Preeclamptic Patients Alert Zymogen Activation and Cell Surface Targeting

Corin is a membrane-bound serine protease that acts as the atrial natriuretic peptide (ANP) convertase in the heart. Recent studies show that corin also activates ANP in the pregnant uterus to promote spiral artery remodeling and prevent pregnancy-induced hypertension. Two CORIN gene mutations, K317...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Dong, Ningzheng, Zhou, Tiantian, Zhang, Yue, Liu, Meng, Li, Hui, Huang, Xiaoyi, Liu, Zhenzhen, Wu, Yi, Fukuda, Koichi, Qin, Jun, Wu, Qingyu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067221/
https://ncbi.nlm.nih.gov/pubmed/24828501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.551424
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