Corin Mutation R539C from Hypertensive Patients Impairs Zymogen Activation and Generates an Inactive Alternative Ectodomain Fragment

Corin is a cardiac transmembrane serine protease that regulates blood pressure by activating natriuretic peptides. Corin variants have been associated with African Americans with hypertension and heart disease. Here, we report a new mutation in exon 12 of the CORIN gene identified in a family of pat...

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Detalhes bibliográficos
Main Authors: Dong, Ningzheng, Fang, Chaodong, Jiang, Yizhi, Zhou, Tiantian, Liu, Meng, Zhou, Jianping, Shen, Jianzhong, Fukuda, Koichi, Qin, Jun, Wu, Qingyu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597824/
https://ncbi.nlm.nih.gov/pubmed/23372161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.411512
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