A Splicing Variant of NME1 Negatively Regulates NF-κB Signaling and Inhibits Cancer Metastasis by Interacting with IKKβ

IKKβ functions as a principal upstream activator of the canonical NF-κB pathway by phosphorylating IκB, leading to its proteasomal degradation. Because IKKβ is considered a therapeutic target, understanding its regulation may facilitate the design of efficient regulators of this molecule. Here, we r...

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Bibliografiske detaljer
Main Authors: You, Dong-Joo, Park, Cho Rong, Lee, Hyun Bok, Moon, Mi Jin, Kang, Ju-Hee, Lee, Cheolju, Oh, Seong-Hyun, Ahn, Curie, Seong, Jae Young, Hwang, Jong-Ik
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067205/
https://ncbi.nlm.nih.gov/pubmed/24811176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.553552
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