Histone Demethylase Jumonji AT-rich Interactive Domain 1B (JARID1B) Controls Mammary Gland Development by Regulating Key Developmental and Lineage Specification Genes

The JmjC domain-containing H3K4 histone demethylase jumonji AT-rich interactive domain 1B (JARID1B) (also known as KDM5B and PLU1) is overexpressed in breast cancer and is a potential target for breast cancer treatment. To investigate the in vivo function of JARID1B, we developed Jarid1b(−/−) mice a...

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Bibliografiske detaljer
Main Authors: Zou, Mike Ran, Cao, Jian, Liu, Zongzhi, Huh, Sung Jin, Polyak, Kornelia, Yan, Qin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067197/
https://ncbi.nlm.nih.gov/pubmed/24802759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.570853
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