The telomerase inhibitor Gno1p/PINX1 activates the helicase Prp43p during ribosome biogenesis

We provide evidence that a central player in ribosome synthesis, the ribonucleic acid helicase Prp43p, can be activated by yeast Gno1p and its human ortholog, the telomerase inhibitor PINX1. Gno1p and PINX1 expressed in yeast interact with Prp43p and the integrity of their G-patch domain is required...

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Sonraí Bibleagrafaíochta
Main Authors: Chen, Yan-Ling, Capeyrou, Régine, Humbert, Odile, Mouffok, Saïda, Kadri, Yasmine Al, Lebaron, Simon, Henras, Anthony K., Henry, Yves
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2014
Ábhair:
RNA
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4066782/
https://ncbi.nlm.nih.gov/pubmed/24823796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku357
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