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The telomerase inhibitor Gno1p/PINX1 activates the helicase Prp43p during ribosome biogenesis
We provide evidence that a central player in ribosome synthesis, the ribonucleic acid helicase Prp43p, can be activated by yeast Gno1p and its human ortholog, the telomerase inhibitor PINX1. Gno1p and PINX1 expressed in yeast interact with Prp43p and the integrity of their G-patch domain is required...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4066782/ https://ncbi.nlm.nih.gov/pubmed/24823796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku357 |
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