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Specificity determinants for the two tRNA substrates of the cyclodipeptide synthase AlbC from Streptomyces noursei
Cyclodipeptide synthases (CDPSs) use two aminoacyl-tRNA substrates in a sequential ping-pong mechanism to form a cyclodipeptide. The crystal structures of three CDPSs have been determined and all show a Rossmann-fold domain similar to the catalytic domain of class-I aminoacyl-tRNA synthetases (aaRSs...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4066775/ https://ncbi.nlm.nih.gov/pubmed/24782519 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku348 |
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