Flexizyme-aminoacylated shortened tRNAs demonstrate that only the aminoacylated acceptor arms of the two tRNA substrates are required for cyclodipeptide synthase activity

Cyclodipeptide synthases (CDPSs) use two aminoacyl-tRNAs (AA-tRNAs) to catalyse cyclodipeptide formation in a ping-pong mechanism. Despite intense studies of these enzymes in past years, the tRNA regions of the two substrates required for CDPS activity are poorly documented, mainly because of two li...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Canu, Nicolas, Tellier, Carine, Babin, Morgan, Thai, Robert, Ajel, Inès, Seguin, Jérôme, Cinquin, Olivier, Vinck, Robin, Moutiez, Mireille, Belin, Pascal, Cintrat, Jean-Christophe, Gondry, Muriel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2020
Onderwerpen:
Nucleic Acid Enzymes
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7672478/
https://ncbi.nlm.nih.gov/pubmed/33095883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa903
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