Genomic analyses of pneumococci from children with sickle cell disease expose host-specific bacterial adaptations and deficits in current interventions

Sickle cell disease (SCD) patients are at high risk of contracting pneumococcal infection. To address this risk, they receive pneumococcal vaccines, and antibiotic prophylaxis and treatment. To assess the impact of SCD and these interventions on pneumococcal genetic architecture, we examined the gen...

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Библиографические подробности
Главные авторы: Carter, Robert, Wolf, Joshua, van Opijnen, Tim, Muller, Martha, Obert, Caroline, Burnham, Corinna, Mann, Beth, Li, Yimei, Hayden, Randall T, Pestina, Tamara, Persons, Derek, Camilli, Andrew, Flynn, Patricia M., Tuomanen, Elaine I., Rosch, Jason W.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4066559/
https://ncbi.nlm.nih.gov/pubmed/24832453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2014.04.005
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