Genomic analyses of pneumococci from children with sickle cell disease expose host-specific bacterial adaptations and deficits in current interventions

Sickle cell disease (SCD) patients are at high risk of contracting pneumococcal infection. To address this risk, they receive pneumococcal vaccines, and antibiotic prophylaxis and treatment. To assess the impact of SCD and these interventions on pneumococcal genetic architecture, we examined the gen...

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Detalhes bibliográficos
Main Authors: Carter, Robert, Wolf, Joshua, van Opijnen, Tim, Muller, Martha, Obert, Caroline, Burnham, Corinna, Mann, Beth, Li, Yimei, Hayden, Randall T, Pestina, Tamara, Persons, Derek, Camilli, Andrew, Flynn, Patricia M., Tuomanen, Elaine I., Rosch, Jason W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4066559/
https://ncbi.nlm.nih.gov/pubmed/24832453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2014.04.005
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