Transient Induction of ING4 by MYC Drives Prostate Epithelial Cell Differentiation and its Disruption Drives Prostate Tumorigenesis

The mechanisms by which Myc overexpression or Pten loss promotes prostate cancer development are poorly understood. We identified the chromatin remodeling protein, ING4, as a crucial switch downstream of Myc and Pten that is required for human prostate epithelial differentiation. Myc-induced transie...

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Detalhes bibliográficos
Main Authors: Berger, Penny L., Frank, Sander B., Schulz, Veronique V., Nollet, Eric A., Edick, Mathew J., Holly, Brittany, Chang, Ting-Tung A., Hostetter, Galen, Kim, Suwon, Miranti, Cindy K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4066454/
https://ncbi.nlm.nih.gov/pubmed/24762396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3076
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