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A dominant mutant allele of the ING4 tumor suppressor found in human cancer cells exacerbates MYC-initiated mouse mammary tumorigenesis
ING4 is a candidate tumor suppressor gene that is deleted in 10–20% of human breast cancers and mutated in various human cancer cell lines. To evaluate whether ING4 has a tumor suppressive role in breast tissue, we over-expressed it in mouse mammary glands using a transplant system. Ectopic expressi...
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Main Authors: | , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2891958/ https://ncbi.nlm.nih.gov/pubmed/20501848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0425 |
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