Inhibition of SREBP Transcriptional Activity by a Boron-Containing Compound Improves Lipid Homeostasis in Diet-Induced Obesity

Dysregulation of lipid homeostasis is intimately associated with obesity, type 2 diabetes, and cardiovascular diseases. Sterol regulatory-element binding proteins (SREBPs) are the master regulators of lipid biosynthesis. Previous studies have shown that the conserved transcriptional cofactor Mediato...

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Detalhes bibliográficos
Main Authors: Zhao, Xiaoping, Xiaoli, Zong, Haihong, Abdulla, Arian, Yang, Ellen S.T., Wang, Qun, Ji, Jun-Yuan, Pessin, Jeffrey E., Das, Bhaskar C., Yang, Fajun
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2014
Assuntos:
Pharmacology and Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4066337/
https://ncbi.nlm.nih.gov/pubmed/24608444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0835
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