Regulation of lipogenesis by cyclin-dependent kinase 8–mediated control of SREBP-1

Altered lipid metabolism underlies several major human diseases, including obesity and type 2 diabetes. However, lipid metabolism pathophysiology remains poorly understood at the molecular level. Insulin is the primary stimulator of hepatic lipogenesis through activation of the SREBP-1c transcriptio...

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Detalhes bibliográficos
Main Authors: Zhao, Xiaoping, Feng, Daorong, Wang, Qun, Abdulla, Arian, Xie, Xiao-Jun, Zhou, Jie, Sun, Yan, Yang, Ellen S., Liu, Lu-Ping, Vaitheesvaran, Bhavapriya, Bridges, Lauren, Kurland, Irwin J., Strich, Randy, Ni, Jian-Quan, Wang, Chenguang, Ericsson, Johan, Pessin, Jeffrey E., Ji, Jun-Yuan, Yang, Fajun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386818/
https://ncbi.nlm.nih.gov/pubmed/22684109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI61462
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