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Duration of treatment and activation of α(1)-containing GABA(A) receptors variably affect the level of anxiety and seizure susceptibility after diazepam withdrawal in rats

Long-term use of benzodiazepine-type drugs may lead to physical dependence, manifested by withdrawal syndrome after abrupt cessation of treatment. The aim of the present study was to investigate the influence of duration of treatment, as well as the role of α(1)-containing GABA(A) receptors, in deve...

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Autors principals: Kovačević, Jovana, Timić, Tamara, Tiruveedhula, Veera V., Batinić, Bojan, Namjoshi, Ojas A., Milić, Marija, Joksimović, Srđan, Cook, James M., Savić, Miroslav M.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4066304/
https://ncbi.nlm.nih.gov/pubmed/24695241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainresbull.2014.03.002
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