PWZ-029, AN INVERSE AGONIST SELECTIVE FOR α(5) GABA(A) RECEPTORS, IMPROVES OBJECT RECOGNITION, BUT NOT WATER-MAZE MEMORY IN NORMAL AND SCOPOLAMINE-TREATED RATS

Inverse agonism at the benzodiazepine site of α(5) subunit-containing GABA(A) receptors is an attractive approach for the development of putative cognition-enhancing compounds, which are still far from clinical application. Several ligands with binding and/or functional selectivity for α(5) GABA(A)...

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Autors principals: Milić, Marija, Timić, Tamara, Joksimović, Srd̄an, Biawat, Poonam, Rallapalli, Sundari, Divljaković, Jovana, Radulović, Tamara, Cook, James M., Savić, Miroslav M.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3556169/
https://ncbi.nlm.nih.gov/pubmed/23261875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbr.2012.12.016
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