Duration of treatment and activation of α(1)-containing GABA(A) receptors variably affect the level of anxiety and seizure susceptibility after diazepam withdrawal in rats

Long-term use of benzodiazepine-type drugs may lead to physical dependence, manifested by withdrawal syndrome after abrupt cessation of treatment. The aim of the present study was to investigate the influence of duration of treatment, as well as the role of α(1)-containing GABA(A) receptors, in deve...

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Détails bibliographiques
Auteurs principaux: Kovačević, Jovana, Timić, Tamara, Tiruveedhula, Veera V., Batinić, Bojan, Namjoshi, Ojas A., Milić, Marija, Joksimović, Srđan, Cook, James M., Savić, Miroslav M.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4066304/
https://ncbi.nlm.nih.gov/pubmed/24695241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainresbull.2014.03.002
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