ESTROGEN METABOLISM BY CYTOCHROME P450 1B1 MODULATES THE HYPERTENSIVE EFFECT OF ANGIOTENSIN II IN FEMALE MICE

To determine the role of CYP1B1 in the gender difference in response to Ang II-induced hypertension, female Cyp1b1(+/+) and Cyp1b1(−/−) mice were infused with Ang II (700 ng/kg/min) or vehicle with/without ovariectomy. In addition, mice were treated with the CYP1B1 inhibitor, 2,3′,4,5′-tetramethoxys...

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Detalhes bibliográficos
Principais autores: Jennings, Brett L., George, L. Watson, Pingili, Ajeeth K., Khan, Nayaab S., Estes, Anne M., Fang, Xiao R., Gonzalez, Frank J., Malik, Kafait U.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065791/
https://ncbi.nlm.nih.gov/pubmed/24777982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.114.03275
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