6β-HYDROXYTESTOSTERONE, A CYTOCHROME P450 1B1 METABOLITE OF TESTOSTERONE, CONTRIBUTES TO ANGIOTENSIN II-INDUCED HYPERTENSION AND ITS PATHOGENESIS IN MALE MICE

Previously, we showed that Cyp1b1 gene disruption minimizes angiotensin II-induced hypertension and associated pathophysiological changes in male mice. This study was conducted to test the hypothesis that cytochrome P450 1B1-generated metabolites of testosterone, 6β-hydroxytestoterone and 16α-hydrox...

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Vydáno v:Hypertension
Hlavní autoři: Pingili, Ajeeth K., Kara, Mehmet, Khan, Nayaab S., Estes, Anne M., Lin, Zongtao, Li, Wie, Gonzalez, Frank J., Malik, Kafait U.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4433413/
https://ncbi.nlm.nih.gov/pubmed/25870196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.115.05396
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