An Overview of the Spindle Assembly Checkpoint Status in Oral Cancer

Abnormal chromosome number, or aneuploidy, is a common feature of human solid tumors, including oral cancer. Deregulated spindle assembly checkpoint (SAC) is thought as one of the mechanisms that drive aneuploidy. In normal cells, SAC prevents anaphase onset until all chromosomes are correctly align...

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Detalhes bibliográficos
Main Authors: Teixeira, José Henrique, Silva, Patrícia Manuela, Reis, Rita Margarida, Moura, Inês Moranguinho, Marques, Sandra, Fonseca, Joana, Monteiro, Luís Silva, Bousbaa, Hassan
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
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Review Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065761/
https://ncbi.nlm.nih.gov/pubmed/24995269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/145289
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