An Overview of the Spindle Assembly Checkpoint Status in Oral Cancer

Abnormal chromosome number, or aneuploidy, is a common feature of human solid tumors, including oral cancer. Deregulated spindle assembly checkpoint (SAC) is thought as one of the mechanisms that drive aneuploidy. In normal cells, SAC prevents anaphase onset until all chromosomes are correctly align...

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Main Authors: Teixeira, José Henrique, Silva, Patrícia Manuela, Reis, Rita Margarida, Moura, Inês Moranguinho, Marques, Sandra, Fonseca, Joana, Monteiro, Luís Silva, Bousbaa, Hassan
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2014
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Review Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065761/
https://ncbi.nlm.nih.gov/pubmed/24995269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/145289
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