Particle Display: A Quantitative Screening Method for Generating High-Affinity Aptamers

We report an aptamer discovery technology that reproducibly yields higher affinity aptamers in fewer rounds compared to conventional selection. Our method (termed particle display) transforms libraries of solution-phase aptamers into “aptamer particles”, each displaying many copies of a single seque...

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Bibliografiske detaljer
Main Authors: Wang, Jinpeng, Gong, Qiang, Maheshwari, Nupur, Eisenstein, Michael, Arcila, Mary Luz, Kosik, Kenneth S., Soh, H. Tom
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065591/
https://ncbi.nlm.nih.gov/pubmed/24644057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201309334
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