Click-Particle Display for Base-Modified Aptamer Discovery

[Image: see text] Base-modified aptamers that incorporate non-natural chemical moieties can achieve greatly improved affinity and specificity relative to natural DNA or RNA aptamers. However, conventional methods for generating base-modified aptamers require considerable expertise and resources. In...

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Publicat a:ACS Chem Biol
Autors principals: Gordon, Chelsea K. L., Wu, Diana, Pusuluri, Anusha, Feagin, Trevor A., Csordas, Andrew T., Eisenstein, Michael S., Hawker, Craig J., Niu, Jia, Soh, Hyongsok Tom
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2019
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6929039/
https://ncbi.nlm.nih.gov/pubmed/31532184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00587
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