Impairment of aldehyde dehydrogenase 2 increases accumulation of acetaldehyde-derived DNA damage in the esophagus after ethanol ingestion

Ethanol and its metabolite, acetaldehyde, are the definite carcinogens for esophageal squamous cell carcinoma (ESCC), and reduced catalytic activity of aldehyde dehydrogenase 2 (ALDH2), which detoxifies acetaldehyde, increases the risk for ESCC. However, it remains unknown whether the ALDH2 genotype...

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Autori principali: Yukawa, Yoshiyuki, Ohashi, Shinya, Amanuma, Yusuke, Nakai, Yukie, Tsurumaki, Mihoko, Kikuchi, Osamu, Miyamoto, Shin’ichi, Oyama, Tsunehiro, Kawamoto, Toshihiro, Chiba, Tsutomu, Matsuda, Tomonari, Muto, Manabu
Natura: Artigo
Lingua:Inglês
Pubblicazione: e-Century Publishing Corporation 2014
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065408/
https://ncbi.nlm.nih.gov/pubmed/24959382
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